New pyrimidine derivatives



United States Patent NEW PYRIMIDINE DERIVATIVES Walter Hepworth,Manchester, England, assignor to Imperial Chemical Industries Limited,London, England, a corporation of Great Britain No Drawing. ApplicationJune 21, 1955, Serial No. 517,055

Claims priority, application Great Britain July 9, 1954 2 Claims. (Cl.260-251) This invention relates to new pyrimidine derivatives. The newpyrimidine derivatives of this invention are those of the formula:

(mafia 01.

Patented Nov. 5, 1957 2 V wherein X has the meaning stated above, to theaction of chlorine.

The invention is illustrated but not limited by the following example inwhich the parts are by weight:

Example 2-chloro-4:6-dimethylpyrimidine is heated to -140 C. and somaintained while a stream of chlorine gas is passed through the moltensubstance until evolution of hydrogen chloride ceases. The product isthen distilled under reduced pressure and a fraction B. P. -161 C./l5mm. is collected, separated and crystallised from ethanol. There isobtained 2-chloro-4:6-bistrichloromethylpyrimidine as a colourlesscrystalline substance, M. P. 100101 C.

What I claim is:

1. A pyrimidine derivative of the formula:

aha-m c 01,

wherein X stands for a chlorine atom.

2. Process for the manufacture of2-chloro-4z6-bistrichloromethylpyrimidine which comprises subjecting apyrimidine derivative of the formula:

alarm-0H8 wherein X stands for a chlorine atom, to the action ofchlorine.

No references cited. a

1. A PYRIMIDINE DERIVATIVE OF THE FORMULA: